In the United Kingdom, most hemodialysis patients currently receive facility-based dialysis costing more than £36,350 per year, including patient transport. We found that the Quanta System (previously known as the SC+) offers improved cost-effectiveness for both 3-weekly and 3.5-weekly self-care dialysis performed at home or as self-care, in-center versus fully assisted dialysis provided 3 weekly with conventional machines in facilities.