As part of the Quanta System’s (previously known as the SC+) design validation, human factors testing was performed with 17 healthcare professionals (nephrology nurses and healthcare assistants) and 15 home users (patients and caregivers). To assess usability and safety, the human factors testing involved between 4.5 and 6 hours of training and, after a period of training decay, a subsequent test session in which participants independently performed tasks on the Quanta System. Between the 2 user groups, there were only 29 errors observed out of 1216 opportunities for errors, despite minimal training. Errors that did occur were minor and attributed to an initial lack of familiarity with the device; none were safety related. Among prevalent dialysis patients and healthcare professionals, the hemodialysis system was easy to use, even with minimal training and a learning decay period, and had a high level of use safety.